Protein homeostatis: live long, won't prosper - Martin W. Hetzer
Protein turnover is an effective way of maintaining a functional proteome, as old and potentially damaged polypeptides are destroyed and replaced by newly synthesized copies. The discovery that NPCs contained long-lived proteins was a surprise because, unlike crystallins, collagens and elastins, NPC components are intracellular structures and are ubiquitously expressed.
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